lipoatrophic diabetes

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[lip′ō·atrof′ik]

an inherited disease characterized by a total loss of subcutaneous body fat, insulin-resistant diabetes mellitus, acanthosis nigricans, hypermetabolism, hepatomegaly, and hypertrophied musculature. It is associated with a disorder of the hypothalamus that results in excessive blood levels of growth hormone and adrenocorticotropic-releasing hormones. Also called congenital total lipodystrophy.

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