leontiasis ossea

(redirected from Lion face)


A condition, either congenital or acquired, in which the head is abnormally large; usually applied to an adult cranium with a capacity of over 1450 mL.
[mega- + G. kephalē, head]

McCune-Albright syndrome

An autosomal dominant condition (OMIM:174800) due to altered regulation of cAMP, endocrinopathy (e.g., hyperthyroidism) and hypophosphatemia.

Clinical findings
Precocious puberty, polyostotic (cystic fibrous dysplasia) spontaneous fractures at young age, café-au-lait spots on skin, ovarian cysts.
Cyclical 4–6-week fluctuations of plasma oestrogen; afflicted young girls have decreased gonadotropins, decreased response to LH-RH; increased testosterone, increased alkaline phosphatase.
Molecular pathology
Defects in GNAS, which encodes a G protein that modulates various membrane signalling cascasdes, cause McCune-Albright syndrome.

Aromatase inhibitor testolactone.

leontiasis ossea

Enlargement and distortion of facial bones, giving one the appearance of a lion. It can occur as a complication of hyperparathyroidism, Paget's disease, uremia, and other conditions.
See also: leontiasis

leontiasis ossea

(lē´əntī´əsis os´ēə),
n an enlargement of the bones of the face, leading to a lionlike appearance. Osseous encroachment may cause obliteration of sinuses, blindness, and malocclusion.
References in periodicals archive ?
These include the Rolls-Royce hallmark, the lion face issued by the London Assay Office, and the '925' and lion body hallmarks - both of which guarantee the minimum 92.
When the cakes are cool cut the chocolate cake into a lion face shape.
For, behind a small lion face on a stone column masquerading as a dormant fountain sits the steep Berendo Stairway, the first of the walk's significant climbs.
FACTUAL Madagascan lemurs bounce through an arid forest, a three-toed sloth goes for a swim (above), a ravenous lion faces down its giraffe prey The extreme forces that shape life are captured in awe-inspiring glory in the second series of Planet Earth.
It is thought Lion faces a similar legal bill for its costs.
Remarkable stonework, which includes carved lion faces and garland bas-relief, is dominant throughout the property.