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linker
(redirected from Linkers)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
linkĀ·er (lngkr)
n.
A fragment of synthetic DNA containing a restriction site that may be used for splicing of genes.

linker
Etymology: ME, linke, connection
a small segment of synthetic DNA used to join DNA fragments in cloning.


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The topics include delineating protease functions during cancer development, positional scanning synthetic combinatorial libraries for substrate profiling, imaging specific cell surface protease activity in living cells using re-engineered bacterial cytotoxins, and on-demand cleavable linkers for radio-immunotherapy.
The '023 patent claims a method of amplifying nucleic acids by attaching DNA linkers of a known sequence to the ends of unknown DNA sequences which are targeted for amplification.
Senter and his coworkers at Seattle Genetics have done an excellent job at developing such linkers for use with several potent and novel drug classes.
 
 
 
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