paraneoplastic limbic encephalitis

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paraneoplastic limbic encephalitis

Abbreviation: PNLE
A brain disorder occurring in some patients with cancer, characterized by the rapid onset of memory loss, often with temporal lobe disease, seizures, delirium, or disturbances of mood. Patients with PNLE often have antibodies against tumor antigens that also react with nerve cell antigens. In some patients the neurological disorder improves after treatment of the responsible tumor.
See also: encephalitis
References in periodicals archive ?
Morgan was then diagnosed with Sero-negative Limbic encephalitis with bilateral temporal lobe involvement - a very rare and cruel condition affecting a small number of people each year.
Limbic encephalitis (LE) was first described by Brierley in 1960 and its association with cancer was first noted in 1968, which was characterized by subacute progressive impairment of short-term memory, psychiatric features, and seizures.
Differentiation of HSE in imaging should consider limbic encephalitis, gliomatosis cerebri, cerebral ischemia, cerebral edema after seizure episodes, and MELAS syndrome (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes), among others.
AIE includes a heterogeneous group of encephalitic syndromes, which generally include two major categories: classic paraneoplastic limbic encephalitis (LE) associated with the so-called well-characterized onconeural autoantibodies against intracellular neuronal antigens (e.
Differential Diagnosis: Limbic encephalitis [LE] represents para neoplastic syndrome caused due to non-CNS primary tumors resulting in functional and imaging changes in the limbic system.
Neurological paraneoplastic syndromes[1] first described by Oppenheim in 1888 mainly include limbic encephalitis, stiff person syndrome, peripheral neuropathy, cerebellar degeneration.
Antibodies to Kv1 potassium channel-complex proteins leucinerich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia.
The current neurological presentation is due to paraneoplastic limbic encephalitis.
Limbic Encephalitis in a 41 Year-Old Female with a Mediastinal Mass and Behavior Changes
SAN FRANCISCO -- Limbic encephalitis, which is usually blamed on an immune response to a tumor, also occurs in patients with no evidence of a tumor, Dr.
sup][2] Faciobrachial dystonic attacks were often seen in limbic encephalitis associated with positive VGKC/LgI1 antibodies.