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ligase |
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ligase /li·gase/ (li´gas) (lig´as) any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate.
ligase an enzyme that repairs single-strand nicks in duplex DNA and covalently joins DNA fragments with complementary, overlapping (called also cohesive or sticky) ends or less efficiently, with blunt ends. Bacteriophage T4 ligase catalyzes the formation of a covalent phosphodiester bond between adjacent 5'-phosphate and 3'-hydroxyl groups in duplex DNA. ligase chain reaction a technique for detecting a specific nucleotide pair in a gene. Called also LCR. |
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| The lack of measurable effects of PM on DNA strand breaks may be due to the very rapid repair by ligases, whereas guanine oxidation is repaired relatively slowly by base excision followed by strand nicking, insertion of nucleotide(s) in the gap, and rejoining by ligases (Hoeijmakers 2001; Risom et al. These include restriction endonucleases for cleaving DNA and ligases for joining the fragments, recombinases that can execute a large variety of DNA cleavage and joining reactions. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. |
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