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ligases

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ligases
[lī′gāsəz]
Etymology: L, ligare + Fr, diastase, enzyme
a group of enzymes that catalyze the formation of a bond between substrate molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar donor molecule. Examples of ligases include the synthetase enzymes.


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These lesions create a barrier for DNA polymerases and ligases to replace missing bases and seal the breaks because these enzymes have a strict requirement for the presence of a 3¶-hydroxyl group and in addition DNA ligases require a 5¶-phosphate group (12, 13).
All DNA polymerases and ligases characterized to date are highly selective for the type of DNA ends that can be utilized.
She said that, in humans, the SIAH ubiquitin ligases sit smack in the middle of the molecular pathway that leads to pancreatic cancer.
 
 
 
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