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Leydig cell hyperplasia

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Leydig cell hyperplasia
Endocrinology Autonomous hyperplasia and hyperfunction of Leydig cells Etiology Activating mutation of LH receptor gene Clinical Precocious puberty Management Orchidectomy


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Leydig cell tumor differs from Leydig cell hyperplasia by being solitary, whereas nodular Leydig cell hyperplasia is characteristically multifocal.
Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances.
In mice at a dose of 25 mg/kg/day (23 times the human exposure, estimated) and in rats at a dose of greater than or equal to 40 mg/kg/day (39 times the human exposure) an increase in the incidence of Leydig cell hyperplasia was observed.
 
 
 
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