Effect of glutathione redox state on Leydig cell
susceptibility to acute oxidative stress.
The mutation was absent in the testicular, juvenile GCT; the Leydig cell
tumors; and the Sertoli-Leydig cell
nuclear area and number of mature Leydig cells
were decreased by 60.
The process of spermatogenesis depends on somatic testicular Leydig cells
and Sertoli cells that control germ cell development (Sharpe et al.
IGCNU and Leydig cell
hyperplasia are frequently present.
The number of sertoli and leydig cells
per testis declines by 40% (22) and 44%, (23) respectively, in elderly males, which may impair spermatogenesis in the elderly.
Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells
," Journal of Andrology 31(4): 365-371.
The amount of testosterone secreted per Leydig cell
was found to be much lower in male offspring after early-life exposure to BPA than in offspring from control unexposed animals.
Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or Leydig cell
testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess.
The movement of testis into the scrotum is under Leydig cell
control around week 12, then testosterone from week 25.
Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit Leydig cell
steroidogenesis via perturbation of mitochondria.
Additionally, inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) further inhibit Leydig cell