Effect of glutathione redox state on
Leydig cell susceptibility to acute oxidative stress.
The mutation was absent in the testicular, juvenile GCT; the
Leydig cell tumors; and the Sertoli-
Leydig cell tumors.
Leydig cells nuclear area and number of mature
Leydig cells were decreased by 60.
The process of spermatogenesis depends on somatic testicular
Leydig cells and Sertoli cells that control germ cell development (Sharpe et al.
IGCNU and
Leydig cell hyperplasia are frequently present.
The number of sertoli and
leydig cells per testis declines by 40% (22) and 44%, (23) respectively, in elderly males, which may impair spermatogenesis in the elderly.
Glucocorticoid suppresses steroidogenesis in rat progenitor
Leydig cells," Journal of Andrology 31(4): 365-371.
The amount of testosterone secreted per
Leydig cell was found to be much lower in male offspring after early-life exposure to BPA than in offspring from control unexposed animals.
Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or
Leydig cell testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess.
The movement of testis into the scrotum is under
Leydig cell control around week 12, then testosterone from week 25.
Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit
Leydig cell steroidogenesis via perturbation of mitochondria.
Additionally, inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) further inhibit
Leydig cell testosterone production.
