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Lewy bodies |
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Lewy bodies [lā′wē, lo̅o̅′ē] Etymology: Frederick H. Lewy, German neurologist, 1885-1950 concentric spheres found inside vacuoles in midbrain and brainstem neurons of patients with idiopathic parkinsonism, Alzheimer's disease, and other neurodegenerative conditions. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Rats with these lesions had cytoplasmic inclusions containing [alpha]-synuclein in the nigral neurons, which resembled the pale body precursors to Lewy bodies found in humans with PD. [17] In MSA, argyrophilic cellular inclusions can be found in oligodendrocytes throughout the damaged structures of the central nervous system,[4] whereas Lewy bodies are more often absent. Instead of examining people who had inherited the brain disorder, the researchers scrutinized Lewy bodies from Parkinson's patients who did not have a mutation in the alpha-synuclein gene. |
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