lacrimo-auriculo-dento-digital syndrome

(redirected from Levy-Hollister syndrome)

lacrimo-auriculo-dento-digital syndrome

An autosomal dominant form (OMIM:149730) of ectodermal dysplasia (a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures) characterised by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. Other findings include facial dysmorphism and malformations of the kidneys, lungs and genitalia.
 
Molecular pathology
Defects in FGF10 on chromosome 5p13-p12, which encodes fibroblast growth factor 10, cause LADDS.
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References in periodicals archive ?
Within the medical literature there are less than 50 reported cases of LADD syndrome, also known as the Levy-Hollister syndrome.
Shiang and Holmes [1977] described absence of the parotid glands and Stensen's ducts in one of two patients with the Levy-Hollister syndrome.