Levitra


Also found in: Dictionary, Thesaurus, Wikipedia.

vardenafil hydrochloride

Levitra

Pharmacologic class: Phosphodiesterase-5 (PDE5) inhibitor

Therapeutic class: Erectile dysfunction agent

Pregnancy risk category B

Action

Selectively blocks PDE5, which neutralizes cyclic guanosine monophosphate, resulting in enhanced erectile function

Availability

Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg

Indications and dosages

Erectile dysfunction

Adult males: 10 or 20 mg P.O. approximately 1 hour before anticipated sexual activity. Maximum dosing frequency is once daily.

Dosage adjustment

• Patients older than age 65
• Concurrent use of CYP450-3A4 inhibitors
• Concurrent HIV therapy (except highly active antiretroviral therapy)

Contraindications

• Hypersensitivity to drug
• Concurrent use of nitrates or nitrate patches to treat angina
• Concurrent use of alpha-adrenergic blockers

Precautions

Use cautiously in:
• cardiovascular disease, retinitis pigmentosa, hepatic or renal impairment, reduced hepatic blood flow
• patients at increased risk for priapism (as from sickle-cell disease, leukemia, multiple myeloma, polycythemia, or history of priapism).

Administration

• Advise patient not to take more than one tablet daily.

Adverse reactions

CNS: headache

CV: hypotension

EENT: blurred vision, altered color perception, light sensitivity, rhinitis

GI: dyspepsia

Skin: flushing

Other: flulike symptoms

Interactions

Drug-drug.Alpha-adrenergic blockers, nitrates: hypotension

Erythromycin, itraconazole, ketoconazole, protease inhibitors: increased vardenafil blood level

Drug-diagnostic tests.Creatine kinase: increased level

Patient monitoring

• Monitor blood pressure and heart rate, particularly if patient has cardiovascular disease.

Patient teaching

• Tell patient he may take with or without food.
• Instruct patient to take one tablet about 1 hour before anticipated sexual activity. Caution him not to take more than one tablet daily.
• Instruct patient to promptly contact prescriber if erection lasts more than 4 hours, because irreversible damage to penis may occur.
• Caution patient not to take nitrates. Tell him to inform prescriber of other drugs he's taking.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Levitra

(lə-vē′trə)
A trademark for the drug vardenafil hydrochloride.

Levitra

a trademark for vardenafil.
A cGMP-specific phosphodiesterase type 5 inhibitor used to manage erectile dysfunction, taken ±1 hour before anticipated sexual activity; it is apparently effective for diabetics
Adverse effects Headache, dyspepsia, nausea, rhinitis

Levitra

A brand name for VARDENAFIL.
References in periodicals archive ?
Levitra is sold in the US by GlaxoSmithKline PLC and Schering-Plough Corp and outside the US by Bayer AG.
The firm said the growth in sales of Levitra ( a competitor to high-profile pill Viagra ( had not kept pace with its other blockbuster treatments for illnesses such as asthma and diabetes.
While Viagra and Levitra ads have taken the macho approach, Lilly is leaning more toward an emphasis on romance, realizing that while men are the users, the women in their lives also have a keen interest in the sale.
Levitra will start competing with Pfizer's Viagra ``as soon as possible'' and Glaxo and Bayer believe they could see sales of more than $1bn.
Levitra, produced by drugs giants GlaxoSmithKline and Bayer, is awaiting final approval from the regulators and should be on the market early next year.
They uncovered 47 suspected cases of sensorineural hearing loss - a rapid loss of hearing in one or both ears - linked to Viagra and related drugs Cialis and Levitra.
Then a short course of tablets such as Levitra, Cialis or Viagra should give you back your erections and help improve your confidence again.
To sell the erectile dysfunction drug Levitra in Hong Kong, the Wall Street Journal reports, Bayer HealthCare AG has had to tailor its message to the local culture in unexpected ways.
The 2001 edition preceded the introduction of Viagra's competitors, Levitra and Cialis, for treating erectile dysfunction (ED).
The group also launched two new products in the US,including an enhanced version of Wellbutrin and Levitra - a drug to treat erectile dysfunction which it hopes will seize market share from Viagra, produced by rivalPfizer.
And aren't the folks at Levitra, the title sponsor for the Skins Game, just pleased as punch that Annika Sorenstam came up second?
Viagra and Levitra, an erectile dysfunction drug approved by the Food and Drug Administration in August, work by increasing blood flow to the penis.