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R-albuterol; a β-adrenergic agent used as the hydrochloride salt as a bronchodilator for treatment and prophylaxis of bronchospasm in reversible obstructive airway disease.


(leev-al-byoo-ter-ole) ,


(trade name),

Xopenex HFA

(trade name)


Therapeutic: bronchodilators
Pharmacologic: adrenergics
Pregnancy Category: C


Bronchospasm due to reversible airway disease (short-term control agent).


R-enantiomer of racemic albuterol. Binds to beta-2 adrenergic receptors in airway smooth muscle leading to activation of adenylcyclase and increased levels of cyclic-3', 5'-adenosine monophosphate (cAMP). Increases in cAMP activate kinases, which inhibit the phosphorylation of myosin and decrease intracellular calcium. Decreased intracellular calcium relaxes bronchial smooth muscle.

Therapeutic effects

Relaxation of airway smooth muscle with subsequent bronchodilation.
Relatively selective for beta-2 (pulmonary) receptors.


Absorption: Some absorption occurs following inhalation.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in the liver to an inactive sulfate and 3–6% excreted unchanged in the urine.
Half-life: 3.3–4 hr.

Time/action profile (bronchodilation)

Inhaln10–17 min90 min5–6 hr


Contraindicated in: Hypersensitivity to levalbuterol or albuterol.
Use Cautiously in: Cardiovascular disorders (including coronary insufficiency, hypertension, and arrhythmias);History of seizures;Hypokalemia;Hyperthyroidism;Diabetes mellitus;Unusual sensitivity to adrenergic amines; Obstetric / Lactation / Pediatric: Pregnancy, lactation, or children <6 yr (for nebulized solution) or <4 yr (for metered-dose inhaler) (safety not established).
Exercise Extreme Caution in: Concurrent use or use within 2 weeks of tricyclic antidepressants or MAO inhibitors (may ↑ risk of adverse cardiovascular reactions).

Adverse Reactions/Side Effects

Central nervous system

  • anxiety
  • dizziness
  • headache
  • nervousness


  • paradoxical bronchospasm (excessive use of inhalers) (life-threatening)
  • increased cough
  • turbinate edema


  • tachycardia


  • dyspepsia
  • vomiting


  • hyperglycemia

Fluid and Electrolyte

  • hypokalemia


  • tremor


Drug-Drug interaction

Concurrent use or use within 2 weeks of tricyclic antidepressants or MAO inhibitors may ↑ risk of adverse cardiovascular reactions (use with extreme caution).Beta blockers block the beneficial pulmonary effects of adrenergic bronchodilators (choose cardioselective beta blockers if necessary and with caution).May ↑ risk of hypokalemia from potassium-losing diuretics.May ↓ serum digoxin levels.May ↑ risk of arrhythmias with hydrocarbon inhalationanesthetics or cocaine.Use with caffeine-containing herbs (guarana, tea, coffee) ↑ stimulant effect.


Inhalation (Adults and Children ≥4 yr) 2 inhalations q 4–6 hr; some patients may respond to 1 inhalation q 4 hr.
Inhalation (Adults and Children >12 yr) 0.63 mg via nebulization 3 times daily (every 6–8 hr); may be ↑ to 1.25 mg 3 times daily (every 6–8 hr).
Inhalation (Children 6–11 yr) 0.31 mg via nebulization 3 times daily (not to exceed 0.63 mg 3 times daily).

Availability (generic available)

Metered-dose inhaler: 45 mcg/actuation in 15-g (200 metered actuations) canisters Cost: $54.23 / 15 g
Inhalation solution: 0.31 mg/3 mL in green foil pouch containing 12 vials, 0.63 mg/3 mL in yellow foil pouch containing 12 vials, 1.25 mg/3 mL in red foil pouch containing 12 vials, 1.25 mg/0.5 mL in unit-dose vials Cost: Generic — All strengths $6.71 / 3 mL

Nursing implications

Nursing assessment

  • Assess lung sounds, pulse, and BP before administration and during peak of medication. Note amount, color, and character of sputum produced. Closely monitor patients on higher dose for adverse effects.
  • Monitor pulmonary function tests before initiating therapy and periodically during course to determine effectiveness of medication.
  • Observe for paradoxical bronchospasm (wheezing, dyspnea, tightness in chest). If condition occurs, withhold medication and notify health care provider immediately.
  • Lab Test Considerations: May cause ↑ serum glucose and ↓ serum potassium.

Potential Nursing Diagnoses

Ineffective airway clearance (Indications)


  • Inhalation: Allow at least 1 min between inhalations of aerosol medication.
    • For nebulization, levalbuterol solution does not require dilution prior to administration. Once the foil pouch is opened, vials must be used within 2 weeks; open vials may be stored for 1 week. Discard vial if solution is not clear or colorless.

Patient/Family Teaching

  • Instruct patient in the proper use of metered-dose inhaler and nebulizer (see ) and to take levalbuterol as directed. Caution patient not to exceed recommended dose; may cause adverse effects, paradoxical bronchospasm, or loss of effectiveness of medication.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking any OTC medications or alcoholic beverages concurrently with this therapy. Caution patient also to avoid smoking and other respiratory irritants.
  • Instruct patient to contact health care professional immediately if shortness of breath is not relieved by medication or is accompanied by diaphoresis, dizziness, palpitations, or chest pain.
  • Advise patients to use levalbuterol first if using other inhalation medications, and allow 5 min to elapse before administering other inhalant medications unless otherwise directed.
  • Advise patient to rinse mouth with water after each inhalation dose to minimize dry mouth.
  • Instruct patient to notify health care professional if no response to the usual dose of levalbuterol.

Evaluation/Desired Outcomes

  • Prevention or relief of bronchospasm.


/lev·al·bu·ter·ol/ (lev″al-bu´ter-ol) R- albuterol; a β-adrenergic agent used as the hydrochloride salt as a bronchodilator for the treatment and prophylaxis of reversible bronchospasm.


an adrenergic beta2-agonist.
indications It is used in the treatment and prevention of bronchospasm (reversible obstructive airway disease).
contraindications Tachydysrhythmias, severe cardiac disease, and known hypersensitivity to sympathomimetics prohibit its use.
adverse effects Among adverse effects are insomnia, headache, dizziness, stimulation, hallucinations, flushing, irritability, dry nose, irritation of the nose and throat, palpitations, tachycardia, hypertension, angina, hypotension, arrhythmias, heartburn, nausea, vomiting, and muscle cramps. Common side effects include tremors, anxiety, and restlessness.
References in periodicals archive ?
Efficacy of racemic albuterol versus levalbuterol used as a continuous nebulization for the treatment of acute asthma exacerbations: a randomized, double-blind, clinical trial.
Reddy's Laboratories (NYSE:RDY) reported on Wednesday the market availability of Levalbuterol Inhalation Solution, USP 0.
Other short- acting beta agonists used for asthma include levalbuterol (Xopenex HFA) and pirbuterol (Maxair Autohaler).
HFA inhalers now on the market include products delivering beclomethasone, fluticasone, fluticasone/salmeterol, levalbuterol, and formoterol/budesonide.
2 million for sales of XOPENEX(R) brand levalbuterol HCl Inhalation Solution and $83.
Food and Drug Administration (FDA) has approved Xopenex[R] brand levalbuterol HCI inhalation solution for the treatment or prevention of bronchospasm in children 6 to 11 years old with reversible obstructive airway disease, such as asthma.
It can be also argued that the recent availability of Levalbuterol (the R enantiomer of salbutamol) as a medication in some countries (35) might open the door to its prohibited oral use to escape detection by the present method.
Teva's recent generic introductions and their respective brand equivalents include: lansoprazole delayed-release capsules, USP; amoxicillin capsules, USP; and clarithromycin tablets, USP (Prevpac kit); temozolomide capsules (Temodar capsules); acitretin capsules, USP (Soriatane capsules); sildenafil tablets (Revatio tablets); levalbuterol Inhalation Solution, USP (Xopenex Inhalation Solution); olanzapine and fluoxetine capsules, USE 3 mg/25 mg (Symbyax Capsules)
Pharmaceutical company Mylan Inc (NasdaqGS:MYL) reported on Monday the receipt of final approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Levalbuterol Inhalation Solution USP, 0.