LEP


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LEP

A gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.

Molecular pathology
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.

LEP

low egg passage, with reference to virus attenuation usually for vaccine production.
References in periodicals archive ?
LEPs were established by the Government to bring together businesses and local authorities to drive private-sector led growth and job creation.
Durham County Council leader Simon Henig, who is chair of the North East Combined Authority, said: "I wholeheartedly support Andrew's appointment to lead the LEP through the next phase.
Simon Henig, chairman of the combined authority and leader of Durham County Council, said: "The local government representatives on the LEP were unable to attend the last board meeting.
Business led LEPs will continue to have a critical role in shaping and implementing devolution deals.
Other combined authorities, such as Greater Manchester, the North East and the Liverpool City Region authorities, have a single LEP with the same boundaries.
The wireless revolution has provided cost effective, efficient and reliable solid-state amplifiers that make LEP light sources possible today.
Their LEP plan is a different way of working to what has been experienced over the last 10-20 years in that it is a blank sheet of paper and they are saying 'tell us what you want'.
Recommendation: To comply with the Executive Order and provide recipient guidance for DHS's components such as FEMA to follow when assessing the need to provide language access services for their programs, services, and activities, the Secretary of Homeland Security should finalize and issue the department's LEP plan and recipient guidance.
Neopharm continues to evaluate whether to extend Phase II trials of LEP or to start a Phase III randomised trial with free Taxol as a comparator arm in metastatic breast cancer patients, Rahman said.
The LEP transmissions offer three reverse ratios with an overall ratio coverage of 14.
In the year 2000, the number of LEP (Limited English Proficient) students nationwide was estimated at 2.
Cambridge Display Technology (CDT), the owner and licensor of the fundamental intellectual property in light emitting polymer (LEP) OLED technology, and DuPont Displays, a business unit of DuPont, have announced an agreement to provide CDT's full color ink jet printing manufacturing technology to DuPont for use in its LEP OLED manufacturing.