silibinin

(redirected from Legalon)

silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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In addition, silymarin-type drugs like legalon have been used for the treatment of acute hepatitis and nonalcoholic fatty liver disease in patients (El-Kamary et al.
Leading Madaus products are Agiolax, Legalon, Reparil and Echniacin.
Protective effect of Legalon in workers exposed to organic solvents.