Lecithin cholesterol acyltransferase | definition of Lecithin cholesterol acyltransferase by Medical dictionary
lecithin-cholesterol acyltransferase (redirected from Lecithin cholesterol acyltransferase)
lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase (LCAT), (les'i-thin-kō-les'tĕr-ōl as'ĭl-trans'fĕr-ās),
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.
lecithin–cholesterol acyltransferase /lec·i·thin–cho·les·ter·ol ac·yl·trans·fer·ase/ (LCAT) (kah-les´ter-ol a″sil-trans´fer-ās) an enzyme that catalyzes the formation of cholesteryl esters in high-density lipoproteins; deficiency of enzyme activity, an inherited disorder, results in accumulation of cholesterol and phosphatidylcholine in plasma and tissues, which causes corneal opacities, anemia, and often proteinuria.
References in periodicals archive
HDL]) by lecithin cholesterol acyltransferase (LCAT) in plasma containing only HDLs (9).
Assays of lecithin cholesterol acyltransferase (LCAT).
The activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase increased significantly in contrast to the activities of lipoprotein lipase and lecithin cholesterol acyltransferase