Leber hereditary optic atrophy

Le·ber he·red·i·tar·y op·tic at·ro·phy

(lā'bĕr), [MIM*535000]
degeneration of the optic nerve and papillomacular bundle with resulting loss of central vision and blindness, progressive for several weeks, then usually becoming stationary with permanent central scotoma; the age of onset is variable, most often in the third decade; more males than females are affected. Mitochondrial or cytoplasmic inheritance through the maternal lineage, caused by mutation in the mitochondrial gene(s) acting autonomously or in association with each other.

Le·ber he·red·i·tar·y op·tic at·ro·phy

(lā'bĕr hĕr-ed'i-tar-ē op'tik at'rŏ-fē)
Degeneration of the optic nerve and papillomacular bundle with resulting loss of central vision and blindness, which is progressive for several weeks, then usually becomes stationary with permanent central scotoma; the age of onset is variable, most often in the third decade; more males than females are affected.

Leber,

Theodor, German ophthalmologist, 1840-1917.
amaurosis congenita of Leber - an autosomal recessive cone-rod abiotrophy causing blindness or severely reduced vision at birth.
Leber hereditary optic atrophy - hereditary degeneration of the optic nerve and papillomacular bundle, resulting in rapid loss of central vision.
Leber idiopathic stellate neuroretinitis - a unilateral neuroretinitis with perifoveal exudates in Henle nerve fiber layer producing a macular star and spontaneous regression in a few months. Synonym(s): stellate neuroretinitis
Leber plexus - a small venous plexus in the eye between the venous sinuses of the sclera (of Schlemm) and the spaces of the iridocorneal angle (of Fontana).
References in periodicals archive ?
Development of reverse dot-blot system for screening of mitochondrial DNA mutations associated with Leber hereditary optic atrophy.