atrophy /at·ro·phy/ (at´ro-fe)
1. a wasting away; a diminution in the size of a cell, tissue, organ, or part.
2. to undergo or cause atrophy.
acute yellow atrophy the shrunken, yellow liver which is a complication, usually fatal, of fulminant hepatitis with massive hepatic necrosis.
Aran-Duchenne muscular atrophy spinal muscular a.
bone atrophy resorption of bone evident in both external form and internal density.
Duchenne-Aran muscular atrophy spinal muscular a.
healed yellow atrophy macronodular cirrhosis.
Leber's hereditary optic atrophy see under neuropathy.
lobar atrophy Pick's disease (1).
myelopathic muscular atrophy muscular atrophy due to lesion of the spinal cord, as in spinal muscular atrophy.
olivopontocerebellar atrophy any of a group of progressive hereditary disorders involving degeneration of the cerebellar cortex, middle peduncles, ventral pontine surface, and olivary nuclei. They occur in the young to middle-aged and are characterized by ataxia, dysarthria, and tremors similar to those of parkinsonism.
optic atrophy atrophy of the optic disk due to degeneration of the nerve fibers of the optic nerve and optic tract.
peroneal atrophy , peroneal muscular atrophy Charcot-Marie-Tooth disease.
physiologic atrophy that affecting certain organs in all individuals as part of the normal aging process.
senile atrophy of skin the mild atrophic changes in the dermis and epidermis that occur naturally with aging.
spinal muscular atrophy progressive degeneration of the motor cells of the spinal cord, beginning usually in the small muscles of the hands, but in some cases (scapulohumeral type) in the upper arm and shoulder muscles, and progressing slowly to the leg muscles.
Sudeck's atrophy post-traumatic osteoporosis.
Le·ber's hereditary optic atrophy (l  b rz)n. The degeneration of the optic nerve and papillomacular bundle with resulting rapid loss of central vision, occurring most often in males. |
Leber's hereditary optic atrophy
A mitochondrial inherited bilateral condition, which appears suddenly in healthy people, primarily males, of about the age of 20 and results in a marked loss of vision and ultimately optic atrophy. A very small percentage of people recover some visual acuity in one or both eyes after the disease has run its course (Fig. L6). Syn. Leber's disease; Leber's hereditary optic neuropathy. See optic atrophy; inheritance; mito-chondrion.
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Fig. L6 Leber′s hereditary optic atrophy (From Kanski 2007, with permission of Butterworth-Heinemann)
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