lattice corneal dystrophy
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lat·tice cor·ne·al dys·tro·phy[MIM*122200]
a corneal dystrophy due to localized accumulation of amyloid in a reticular pattern; manifest at puberty and progressing slowly until eventually useful vision is lost; autosomal dominant inheritance, caused by mutation in the transforming growth factor, beta-induced, gene (TGFβI) encoding keratoepithelin on 5q.
corneal dystrophy, lattice type 1An autosomal dominant (OMIM:122200) form of corneal dystrophy characterised by wispy, greyish, cotton-like threads limited to a zone between the centre of the cornea and the periphery, with slowly progressive loss of vision by the fifth or sixth decade of life.
Has been linked to defects of TGFBI, which encodes an RGD protein that binds to type I, II and IV collagens and plays a role in cell–collagen interactions.