Larsen syndrome


Also found in: Wikipedia.

Lar·sen syn·drome

(lar'sĕn),
a syndrome characterized by multiple congenital dislocations with osseous anomalies, including characteristic flattened facies and cleft of the soft palate.

Larsen syndrome

[Loren Joseph Larsen, Am. orthopedic surgeon, b. 1914]
A rare autosomal disorder characterized by multiple joint dislocations and flattening of the face with widely spaced eyes, among other findings.

Larsen,

Loren Joseph, U.S. orthopedic surgeon, 1914–.
Larsen syndrome - characterized by multiple congenital dislocations with osseous anomalies, including characteristic flattened facies and cleft soft palate.
References in periodicals archive ?
Larsen Syndrome is the rare inherited disease of defect in collagen formation.
Larsen syndrome is a rare genetic disease associated with defect in collagen formation.
In this report, we present a case with Larsen syndrome, which was scheduled to undergo inguinal hernia surgery; in addition, the anesthetic management of this syndrome is discussed.
A 7-month-old male infant, weighing 3750 g, diagnosed with Larsen syndrome was scheduled to undergo surgery for bilateral inguinal hernia under general anesthesia.
Patients with Larsen syndrome may require surgery for multiple orthopedic abnormalities (1).
Anesthesia for children with Larsen syndrome can be hazardous.
Volunteer Victoria Marshall, 32, from Lynemouth near Ashington, stayed at Crawford House from October 2012 to May 2013 while her son Dillon, 10, who suffers from Larsen syndrome recovered from a spinal surgery operation.
Larsen syndrome is a rare congenital disorder characterized by multiple large joint dislocations and flattened facies.
Genes that have been implicated in Larsen syndrome include filamin B [2], whichisinvolvedinthe cytoskeletal architecture, and carbohydrate sulphotransferase 3, which has also been implicated in other skeletal dysplasias [3].
Larsen syndrome has been associated with a number of other anomalies, many of which have relevance to the otolaryngologist.
We present a case of Larsen syndrome being associated with ossicular malposition causing a conductive hearing loss.
She had a recent diagnosis of Larsen syndrome, and was homozygous for the CHST3 gene, for which the inheritance is autosomal recessive.