Lambert-Eaton syndrome

Lam·bert-Eaton syndrome (lmbrt-)

n.

Progressive proximal muscle weakness in individuals with carcinoma, in the absence of dermatomyositis or polymyositis. Also called carcinomatous myopathy, Eaton-Lambert syndrome.

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Lambert-Eaton syndrome

Carcinomatous myasthenia, carcinomatous myopathy, myasthenic syndrome Neurology A neuromuscular disorder characterized by chronic progressive muscular weakness usually of legs, aching, fatigability, autonomic dysfunction–dry mouth, impotence, constipation, blurred vision, dyshidrosis, absent deep tendon reflex; LES is often paraneoplastic, and commonly linked to primary lung carcinoma, 'classically' small cell type, but also SCC and adeno CA Management 3,4-Diaminopyridine may be enhance acetylcholine release