Such changes are likely to occur in the hypothalamus, as 5-HT stimulates and DA inhibits the release of PRL from the anterior pituitary lactotrophs
Prolactin synthesis and release from the lactotrophs
are controlled by neurotransmitters which act on the pituitary via hypothalamus.
Pit-1 gene expression is essential for the growth of some regulatory processes in the body of animals such as the ability of normal survival, differentiation and development of the three cell types of adenohypophysis, namely somatotrophs, lactotrophs
and thyrotrophs [2,3].
There are many fish predators in the rice field, such as animals, birds, snakes, Cybister, Lactotrophs
and frogs etc.
Medications such as Reglan[R], Risperdal[R], tricyclic antidepressants, and selective serotonin reuptake inhibitors block dopamine receptors; Aldomet[R] and Serpasil* deplete dopamine; morphine, codeine, and heroin inhibit the release of dopamine; Tagamet[R], Pepcid[R], and Zantac[R] block histamine receptors; and Calan[R], birth control pills, and Depo Provera[R] stimulate lactotrophs
(Pena & Rosenfeld, 2001).
Prolactin is a hormone synthesized in the adenohypohyseal lactotrophs
, has no known target organ or defined role in male reproduction.
Dopamine attaches to D2 receptors, thereby causing arrest of PRL release by lactotrophs
Prolactin is a polypeptide hormone that is secreted by lactotrophs
of the anterior pituitary gland.
Dopamine is known to be the primary regulator of prolactin release from lactotrophs
in the anterior pituitary.
Possibility of spared lactotrophs
getting disinhibited from hypothalamic inhibition or a small prolactinoma located in the pituitary remnant cannot be ruled out with the present day imaging techniques.
Bromocriptine is a semisynthetic ergot alkaloid that binds to receptors on normal and tumor lactotrophs
and inhibits the synthesis and secretion of prolactin.
The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs
as well as in animal experiments.