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storage lesion |
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storage lesion Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.
Storage lesions
↑ Ammonium to 470 µmol/L–US: 800 µg/dL
↑ Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL
↑ K+ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L
↓ ATP from 100% to 45%
↓ 2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion
↓ Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible
↓ Na+ from 169 to 111 mmol/L–US: 169 to 111 mEq/L
↓ pH from 7.6 to 6.7
Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status
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This procedure also produced myosin-Sl suitable for MS and is a more rapid alternative method to exhaustively desalting labile proteins by dialysis. However, because of the very nature of blood-a liquid organ containing numerous labile proteins and fragile cells-and the wide array of potentially infectious agents, no single method of pathogen inactivation will likely preserve all blood components yet effectively kill bacteria, spores, protozoa, prions, and the diverse families of viruses. For example, Fourier transform infrared spectroscopy experiments when conducted on freeze labile proteins have not detected significant changes in their secondary structure (2) presumably because they are carried out at relatively large protein concentrations, a condition in which the perturbation is often attenuated as if the protein itself acted as a stabilizer. |
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