storage lesion (redirected from Labile proteins)

storage lesion

Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.

Storage lesions

↑ Ammonium to 470 µmol/L–US: 800 µg/dL

↑ Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL

↑ K⁺ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L

↓ ATP from 100% to 45%

↓ 2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion

↓ Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible

↓ Na⁺ from 169 to 111 mmol/L–US: 169 to 111 mEq/L

↓ pH from 7.6 to 6.7

Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status