In December 2014, Sanofi announced the FDA approval of Priftin in combination with isoniazide (INH) for the treatment of LTBI
caused by Mycobacterium tuberculosis in patients at high risk of progression to tuberculosis disease.
From a safety perspective, LTBI
treatment is not trivial.
In those with positive screening TSTs, over 90% did not start or complete LTBI
With its higher specificity, fewer HCWs will require LTBI
treatment at baseline screening.
If no signs of active disease are found, they are treated with antibiotics to lessen the odds of reactivation of LTBI
This case was a 30 yr-old woman who developed TB following etanercept treatment for rheumatoid arthritis despite isoniazid prophylaxis for LTBI
Some evidence suggests that immunosuppressive medications and diseases such as rheumatoid arthritis may themselves make a patient with LTBI
anergic, thereby resulting in a false-negative TST.
Unlike standard vented parts, the vacuum-molded samples showed an extended plateau after achieving full cure, with no drop-off in LTBI
Current Diagnosis of Infant Tuberculosis Infection covers problems concerning the diagnosis of LTBI
, giving an overview of commercially available options and, unlike most reviews on this subject, also points out some tools currently under development.
The study's follow-up phase is now underway, and patients with LTBI
will be evaluated for rates of disease and associated risks.
Contract award: Systematic review on effectiveness of interventions to improve initiation, adherence and completion of LTBI
2] The greatest burden of LTBI
is in South-East Asia (46%), the Western Pacific region (32%), Africa (31%) and the Eastern Mediterranean region (27%)  Sub-Saharan Africa, however, has the largest number of persons with LTBI
who are co-infected with HIV.