IRGM

(redirected from LRG47)

IRGM

A gene on chromosome 5q33.1 that encodes immunity-related GTPase family member M (interferon-inducible protein 1), a putative GTPase required for clearing acute protozoan and bacterial infections. IRGM is thought to play a role in the innate immune response by regulating autophagy; it may regulate proinflammatory cytokine production and prevent endotoxaemia upon infection, and it may play a role in macrophages adhesion and motility.

Molecular pathology
Defects in IRGM cause susceptibility to inflammatory bowel disease type 19.