LQT1


Also found in: Acronyms.

KCNQ1

A gene on chromosome 11p15.5 that encodes a voltage-gated potassium channel required for the repolarisation phase of the cardiac action potential. The KCNQ1 gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
 
Molecular pathology
KCNQ1 mutations are associated with hereditary long QT syndrome/Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.

LQT1

, LQT2, LQT3 Molecular medicine Three genes, located on chromosomes 11, 7, and 3 respectively, that have been linked to the long QT syndrome. See Long QT syndrome.
References in periodicals archive ?
For example, patients with a mutation in the LQT1 gene have the highest risk of having a cardiac event by the age of 40 and patients with a mutation in LQT3 have the lowest (1).
Positional cloning[31] was used to identify the LQT1 gene on chromosome 11p15.
For instance, they showed that mutations in LQT1 and LQT2 result in early symptoms (ie, syncope), but the risk of sudden death was relatively low for any event.