LQT1


Also found in: Acronyms.

KCNQ1

A gene on chromosome 11p15.5 that encodes a voltage-gated potassium channel required for the repolarisation phase of the cardiac action potential. The KCNQ1 gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
 
Molecular pathology
KCNQ1 mutations are associated with hereditary long QT syndrome/Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.

LQT1

, LQT2, LQT3 Molecular medicine Three genes, located on chromosomes 11, 7, and 3 respectively, that have been linked to the long QT syndrome. See Long QT syndrome.
References in periodicals archive ?
The mainstay of therapy in patients with LQTS remains beta-blockers, particularly in LQT1 patients.
La actividad fisica, especialmente la natacion esta relacionada con la aparicion de arritmias ventriculares en la presentacion del SQTL con implicacion del gen LQT1, mientras que las personas con la variante LQT2 lo hacen con estres emocional o auditivo.
There were four post partum: three among 46 women with the LQT2 genotype, compared with just one of 101 LQT1 women.
Positional cloning[31] was used to identify the LQT1 gene on chromosome 11p15.
For instance, they showed that mutations in LQT1 and LQT2 result in early symptoms (ie, syncope), but the risk of sudden death was relatively low for any event.