LPAR3

LPAR3

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid, a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion, by Ca2+ mobilisation.
References in periodicals archive ?
AA treatment was also verified to also target proliferative factors LPAR1, LPAR3, LPAR4, LPAR5 and LPAR6.
Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells.
LPAR3 in pigs is expressed in the uterine endometrium and levels of LPAR3 expression increase on day 12 of pregnancy, when the conceptus begins to implant; LPA also increases endometrial PTGS2 expression (Seo et al.
Among these receptors, LPAR3 seems to be a key receptor for conceptus implantation in pigs because LPAR3 expression sharply increases in the uterine endometrium on d 12 of pregnancy, when conceptus implantation begins, and LPA upregulates PTGS2 expression through LPAR3 (Seo et al.