LPAR3

LPAR3

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid, a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion, by Ca2+ mobilisation.
References in periodicals archive ?
LPAR3 in pigs is expressed in the uterine endometrium and levels of LPAR3 expression increase on day 12 of pregnancy, when the conceptus begins to implant; LPA also increases endometrial PTGS2 expression (Seo et al.
Among these receptors, LPAR3 seems to be a key receptor for conceptus implantation in pigs because LPAR3 expression sharply increases in the uterine endometrium on d 12 of pregnancy, when conceptus implantation begins, and LPA upregulates PTGS2 expression through LPAR3 (Seo et al.
Furthermore, we have shown that expression of LPAR3, an estrogen-responsive gene (Seo et al.