LPAR1

(redirected from LPA1)

LPAR1

A gene on chromosome 9q31.3 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid, a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion.
References in periodicals archive ?
En razon a lo anterior, para el primer modelo, correspondiente a la linea de produccion artesanal de la marroquineria del cuero y repujado (Marroquineria LPA1), se puede decir que ser jefe de hogar artesano tiene una probabilidad de 9,8% de pertenecer a la LPA1, en comparacion con aquellos que no son jefes de hogar.
En efecto, en la Tabla 6 se observa que, en terminos de la variable jefe de hogar, la probabilidad de pertenecer a la linea de produccion LPA1 y/o LPA2 disminuye, en comparacion con aquellos que no son jefes de hogar.
Una de las variables que resulto ser estadisticamente significativa en las dos lineas tratadas--a diferencia de lo presentado en la LPA1, en la cual resulto ser estadisticamente insignificante--es la que se refiere al lugar de trabajo (el taller), la cual presenta una relacion inversa en la probabilidad de ocurrencia del evento.
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.
To investigate how LPA exerted this effect, the team produced mice that genetically lack one or both of the two receptors -- LPA1 and LPA2 -- to which LPA can bind on ventricle-building fetal progenitor cells, finding that the LPA1 receptor was required to produce hydrocephalus.
In a final demonstration, the team pre-treated normal fetal mice with a compound that blocks the activation of LPA1 receptors, and found that even after LPA exposure, their signs of hydrocephalus were greatly reduced.
If you had an unborn baby who was at risk from an injury to the mother, an infection, or evidence of bleeding then, in principle, you could treat with a short-acting LPA1 blocker to prevent or reduce hydrocephalus," said Chun.
28 September 2010 - US Amira Pharmaceuticals Inc said yesterday it has filed an Investigational New Drug (IND) application with the US Food and Drug Administration (FDA) for AM152, a novel LPA1 antagonist.
69) The G protein-coupled receptors for lysophosphatidic acid, LPA1 and LPA2, which can signal through nuclear factor [kappa]B or Akt, were recently shown by Yamada et al (70) to be expressed in MPM cell lines and human samples, and the addition of LPA enhanced cell proliferation and motility via LPA1 and LPA2, respectively.
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.
3 606167 No definido accumulation protein) EDG1 S1P1 (S1P 1p21 601974 No definido {Endothelial receptor 1) differentiation gene 1) EDG2 VZG1(ventricular 9q 602282 No definido zone gene 1), LPA1 EDG3 S1P3 9q22.
The maximum nucleotide/amino acid identity between the LPA1 virus A/Mallard/Sweden/56/02 and A/Turkey/Ireland/PV74/95 (H7NT) was 95% nt, 96% aa; between A/Mallard/Sweden/56/02 and A/England/268/96 (H7N7), it was 96% nt and 97% aa.