KCNQ1OT1

(redirected from LIT1)
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KCNQ1OT1

A gene on chromosome 11p15 that is epigenetically regulated and expressed from only one chromosome in a parent-of-origin manner. The KCNQ1OT1 transcript is thought to be non-coding, and regulates bidirectional gene silencing and the spreading of DNA methylation on the paternally inherited chromosome.

Molecular pathology
The transcript is abnormally expressed from both chromosomes (as above) in most patients with Beckwith-Wiedemann syndrome, and occurs in some cancers.
References in periodicals archive ?
Feinberg, IGF2, H19, p57 KIP2, and LIT1 and the Beckwith-Wiedemann Syndrome, in INBORN ERRORS OF DEVELOPMENT: THE MOLECULAR BASIS OF CLINICAL DISORDERS OF MORPHOGENESIS 758, 758-65 (Charles J.
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.