LHX3

LHX3

A gene on chromosome 9q34.3 that encodes a homeobox protein which binds to and activates the promoter of the alpha-glycoprotein gene, synergistically enhancing transcription from the prolactin promoter in co-operation with Pit-1.

Molecular pathology
Defects in LHX3 cause pituitary hormone deficiency combined type 3.