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gonadotropin-releasing hormone analogue
(redirected from LHRH analogue)

   Also found in: Wikipedia 0.01 sec.
gonadotropin-releasing hormone analogue
A polypeptide analogue of gonadotropin-releasing hormone–GnRH; some are more potent than GnRH in stimulating gonadotropin release Examples Leuprolide, histrelin, administered in a pulsatile fashion to restore lost GnRH, normalize pituitary-gonadal function, as in congenital GnRH deficiencies–eg, hypogonadotropic hypogonadism with Kallmann syndrome or without anosmia, or in acquired GnRH deficiency secondary to RT of the CNS, pituitary tumors, or panhypopituitarism. See Gonadotropin-releasing hormone.


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About the partnership The collaboration between Ipsen and Debiopharm started in 1983 with regards to LHRH analogues, in particular for the triptorelin analogue Decapeptyl([R]) (also known as Pamoreline([R]) and Diphereline([R])).
In this Phase II trial, CB7630 in combination with prednisone is administered once daily to chemotherapy-naove, ketoconazole-naove patients with castration-resistant prostate cancer (CRPC), who had progressive disease despite treatment with LHRH analogues and other hormonal therapies.
In this Phase II trial, CB7630 in combination with prednisone is administered once daily to chemotherapy-naove, ketoconazole-naove patients with castration resistant prostate cancer (CRPC), who had progressive disease despite treatment with LHRH analogues and other hormonal therapies.
 
 
 
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