LGR5

LGR5

A gene on chromosome 12q22-q23 that encodes an orphan G protein-coupled receptor that is the stem cell marker of the intestinal epithelium and hair follicles. LGR5 is the target gene of Wnt signalling.
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Defensin (14) has been shown to activate the leucine-rich repeat-containing G-protein-coupled receptors 5 and 6 (also known as LGR5 and LGR6) stem cells.
cerevisiae); CAMK1D, calcium/ calmodulin-dependent protein kinase ID; TSPAN8, tetraspanin 8; LGR5, leucine-rich repeat-containing G protein--coupled receptor 5; THADA, thyroid adenoma associated; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif, 9; NOTCH2, notch 2; KCNQ1, potassium voltage-gated channel, KQT-like subfamily, member 1; MTNR1B, melatonin receptor 1B; CAPN10, calpain 10; ENPP1, ectonucleotide pyrophosphatase/phosphodiesterase 1.
The company claimed the novel stem cell lines include E120 expressing the gene LGR5, useful in colon cancer drug discovery, EN16, T43, RAD20.
A recently identified gene product, LGR5, was shown to be specifically expressed in cycling basal crypt columnar cells in mice and in humans and are believed to represent multipotential stem cells.
These products will include the novel stem cell lines: E120 expressing the gene LGR5 useful in colon cancer drug discovery, EN16, T43, RAD20.
One of these markers, LGR5, has been studied for intestinal stem cells by other researchers who have bred special mice and developed an advanced method that uses a fluorescent protein to follow stem cells.