HNF1B

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HNF1B

A gene on 17q12 that encodes a transcription factor that binds an inverted palindromic sequence of DNA.

Molecular pathology
Defects in HNF1B are a cause of maturity-onset diabetes of the young type 5 (MODY5, or renal cysts and diabetes syndrome) and contribute to the development of type-2 diabetes and prostate cancer hereditary type 11.