IFITM1

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IFITM1

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM1 downregulates IFN-gamma by inhibiting ERK activation, or by arresting p53-dependent cell growth in G1.