LAMC1

LAMC1

A gene on chromosome 1q31 that encodes laminin gamma 1, an extracellular matrix protein that forms a complex with laminin alpha and laminin beta chains, mediating the attachment, migration and organisation of cells into tissues during embryonic development.
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Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer.
Darbo et al found mutations in extracellular matrix genes NIDI and LAMC1 causing autosomal dominant DWM and occipital cephalocoeles in a family by performing whole exome sequencing.
Among the DE-transcripts, COL8A2, COL12A1, COL13A1, LOC424798, LAMA2, LAMA4, LAMB4, and LAMC1 may be related to extracellular matrix formation; while CHST3, GALNTL1, NDST4, LARGE, POFUT2, RCJMB04_28l23, and MAN1A2 are all localized in the endoplasmic reticulum or Golgi apparatus, and likely mediate the processes of carbohydrate metabolism, or posttranslation glycosylation modification.
LAMC1 - the second gene in the laminin gene family found to be associated with colorectal cancer