LAMB3

LAMB3

A gene on chromosome 1q32 that encodes laminin beta 3, an extracellular matrix protein that with an alpha and a gamma subunit forms laminin-5.

Molecular pathology
LAMB3 mutations cause junctional epidermolysis bullosa (Herlitz type), and generalised atrophic benign epidermolysis bullosa.
References in periodicals archive ?
The cells were transduced using a Moloney leukemia virus-derived retroviral vector that expressed the normal full-length LAMB3 gene found to contain a single point mutation in the patient's genetic profile (Nat.
Genomics of Epidermolysis Bullosa EB Type Level of Blistering Genes Simplex Basal cell layer KRT5, KRT14 Hemidesmosomal Basal cell/lamina BPAG2, ITGB4, ITGA6 lucida interface (PLEC1 with muscular dystrophy) Junctional Lamina lucida LAMA3, LAMB3, LAMC2 Dystrophic Sublamina densa COL7A1 Source: Dr.