chronic sclerosing sialadenitis

(redirected from Kuttner tumour)

chronic sclerosing sialadenitis

An uncommon unilateral inflammatory condition affecting the submandibular gland, which may mimic neoplasia.
 
Aetiology
Idiopathic, stones, microliths, infection, immune-related, linked to reduced salivary flow, increased viscosity. Long-standing obstruction causes inflammation leading to acinar atrophy and fibrosis. The most extreme manifestation of this process is the so-called Kuttner tumour—a rock-hard, tumour-like areas of end-stage fibrosis and lymphoplasmacytic inflammation, which may be accompanied by metaplasia (squamous, mucous, ciliated, oncocytic) in the ducts.

DiffDx
Lymphoma, lymphoepithelial lesion.
References in periodicals archive ?
INTRODUCTION: Kuttner tumour was first described in 1896 by H.
DISCUSSION: Kuttner tumour, otherwise known as chronic sclerosing sialadenitis, is a chronic inflammatory disease of the salivary gland characterised by progressive periductal fibrosis, dilated ducts with a dense lymphocyte infiltration and lymphoid follicle formation and acinar atrophy (1).
Tiemann et al (5) support that Kuttner tumour shows the features of an autoimmune process, where the quantity of CD 4 and CD8 positive cells was higher than that of CD3 cells and the number of cytotoxic T cells and macrophages decreased with increasing sclerosis.