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knockout mouse |
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knockout mouse, a mouse that has had a specific gene artificially deleted from its genome. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Using targeted mutations in transgenic mice, scientists began to develop knockout mouse models of human disease to test the role of specific genes in disease etiology and progression (Eddy 1993; Smithies and Kim 1994). Hannon explains that creating a knockout mouse can take well over a year, while knocking down a gene with RNAi takes only a few days. VelociGene uses a proprietary process to create genetic modifications in a mouse in a precise and high-throughput manner and was recently selected by the National Institutes of Health for use in its Knockout Mouse Project. |
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