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knockout mouse
(redirected from Knock-out mouse)

    Also found in: Wikipedia 0.02 sec.
knock·out mouse (nkout)
n.
A transgenic mouse that has been genetically engineered to exhibit mutations in specific genes.
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In their letter, Johnson and Huff point out an important, and appropriate, criticism of the current transgenic and knock-out mouse models: there are several protocol issues that need to be addressed.
"Bioassay bashing is bad science": MacDonald's response. ... by MacDonald, James S. / Environmental Health Perspectives
The manuscript describes a knock-out mouse model in which the interleukin-1 receptor antagonist (IL-1ra) gene has been deleted in the animal.
IL-1 Genetic Link to Artery Disease Supported By Knock-Out Mouse ... by Business Wire
Geron provided funding for development of the original telomerase knock-out mouse which led to this study, and has exclusive intellectual property rights to key human telomerase assays, proteins and genes, as well as therapeutic applications of these molecules.
Telomerase Prevents Onset of Liver Cirrhosis in Mice by Business Wire
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