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knockout mouse
(redirected from Knock-out mouse)

   Also found in: Wikipedia 0.02 sec.
knockĀ·out mouse (nkout)
n.
A transgenic mouse that has been genetically engineered to exhibit mutations in specific genes.

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In their letter, Johnson and Huff point out an important, and appropriate, criticism of the current transgenic and knock-out mouse models: there are several protocol issues that need to be addressed.
The manuscript describes a knock-out mouse model in which the interleukin-1 receptor antagonist (IL-1ra) gene has been deleted in the animal.
Geron provided funding for development of the original telomerase knock-out mouse which led to this study, and has exclusive intellectual property rights to key human telomerase assays, proteins and genes, as well as therapeutic applications of these molecules.
 
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