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knockout mouse |
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knockout mouse, a mouse that has had a specific gene artificially deleted from its genome. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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In their letter, Johnson and Huff point out an important, and appropriate, criticism of the current transgenic and knock-out mouse models: there are several protocol issues that need to be addressed. The manuscript describes a knock-out mouse model in which the interleukin-1 receptor antagonist (IL-1ra) gene has been deleted in the animal. Geron provided funding for development of the original telomerase knock-out mouse which led to this study, and has exclusive intellectual property rights to key human telomerase assays, proteins and genes, as well as therapeutic applications of these molecules. |
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