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knockout mouse |
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Knock-out mice are currently produced by growing embryo-derived pluripotent stem cells in culture, creating targeted mutations in them and then transplanting them into preimplantation mouse embryos to produce a chimera that comprises normal recipient lineages as well as lineages derived from the mutant cells. Following extensive studies, Cognetix scientists used neurotensin receptor knock-out mice to conclusively identify the neurotensin NTR1 receptor as the specific site through which CGX-1160 produces analgesia. Many pharmaceutical and biotech companies have invested in knock-out mice and other mouse models to study human disease and develop drug targets," said Barney Saunders, vice president and general manager, Agilent BioResearch Solutions. |
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Knock-out mice
