kininogen

(redirected from Kininogens)

kininogen

 [ki-nin´o-jen″]
either of two plasma α2-globulins that are kinin precursors. High-molecular-weight (HMW) kininogen (also called Fitzgerald factor) is split by plasma kallikrein to produce bradykinin; low-molecular-weight (LMW) kininogen is split by tissue kallikrein to produce kallidin. Deficiency of HMW kallikrein is a rare condition but may be considered when prolonged activated partial thromboplastin time cannot be explained by deficiencies of other more common factors.

ki·nin·o·gen

(ki-nin'ō-jen'),
The globulin precursor of a plasma kinin.

kininogen

/ki·nin·o·gen/ (ki-nin´o-jen) either of two plasma α2-globulins that are kinin precursors, HMW (high-molecular-weight) k., precursor to bradykinin, and LMW (low-molecular-weight) k., precursor to kallidin.

ki·nin·o·gen

(ki-ninō-jen)
The globulin precursor of a (plasma) kinin.

kininogen

an α2-globulin of plasma that is a precursor of the kinins.
References in periodicals archive ?
Independent consumption of high and low molecular weight kininogens in vivo.
Mechanism of pain of intravenous injection of propofol may be due to its endothelial irritation, osmolality differences, unphysiological pH and activation of pain mediators such as kininogens.
A novel mechanism for bradykinin production at inflammatory sites: diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens.
Under the definition of peptide hormones superfamily, they are defined as the intercellular messengers like adipokines (adiponectin, leptin, resistin), cytokines (chemokines, hematopoietic growth factors, hepatocyte growth factor, interferons, interleukines, lymphokines, monokines, osteopontin, transforming growth factor beta, TNF), endothelial growth factors, endothelins, fibroblast growth factor, quinines (bradykinin, kininogens, tachykinin) and platelet derived growth factor (see, http://www.
The lack of any capillary permeability response may be due to the lack of sufficient endogenous kininogens in the injection area.
2]-GPI and prothrombin, (activated) protein C (12), protein S (12), annexin V (13), high- and low-molecular weight kininogens (14), factor XII (15), thrombomodulin (16), and tissue-type plasminogen activator (17) have been reported to be antigenic targets of aPL antibodies.
These high concentrations were balanced by increased serum cystatin C, which in addition to kininogens and [[alpha].
Contact activation of blood generates kallikrein, an enzyme that can convert kininogens into kinins.
Characterization of kininogens in human malignant ascites.