kinase

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kinase

 [ki´nās]
1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor, and named, according to the acceptor, as creatine kinase, fructokinase, etc.
2. an enzyme that activates a zymogen, named, according to its source, such as enterokinase, streptokinase, etc.

ki·nase

(kī'nās),
1. Enzyme that catalyzes conversion of a proenzyme to an active one (for example, enteropeptidase [enterokinase]). Important in salvage and recycling of nucleotides. Some antiviral agents work by inactivating viral or tumor kinases
2. Suffix attached to some enzymes to indicate transformation.

kinase

/ki·nase/ (ki´nās)
1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor.
2. a suffix used in the names of some enzymes that convert an inactive or precursor form.

kinase

(kī′nās′, -nāz′, kĭn′ās′, -āz′)
n.
Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor protein. Kinases regulate many essential cellular processes.

kinase

[kī′nās]
Etymology: Gk, kinesis, motion; ase, enzyme
1 an enzyme that catalyzes the transfer of a phosphate group or another high-energy molecular group to an acceptor molecule. Each of these kinases is named for its receptor, such as acetate kinase, fructokinase, or hexokinase.
2 an enzyme that activates a preenzyme (zymogen). Each of these kinases is named for its source, such as bacterial kinase, enterokinase, fibrinokinase, insulin kinase, staphylokinase, streptokinase, streptokinase-streptodornase, or urokinase.

ki·nase

(kī'nās)
1. An enzyme catalyzing the conversion of a proenzyme to an active enzyme.
2. An enzyme catalyzing the transfer of phosphate groups to form triphosphates (e.g., adenosine triphosphate).

kinase

See TRANSFERASE.

kinase

an enzyme that catalyses the transfer of a phosphoryl group from ATP to another compound.

kinase

1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor, and named, according to the acceptor, as creatine kinase, fructokinase, etc.
2. an enzyme that activates a zymogen, and named, according to its source, as enterokinase, streptokinase, etc.

protein k's
cellular enzymes which utilize ATP to phosphorylate proteins, usually at a selected OH group of serine, threonine or tyrosine residue in the protein, so as to increase or decrease the activity of the protein.
protein kinase C
membrane bound protein kinase designated C because it requires Ca2+ and phosphatidyl serine for its activity. Activated by sn-1,2-diacylglycerol (DAG) produced from phosphatidyl inositol 4,5-bisphosphate. Phosphorylates target proteins such as the insulin receptor, β-adrenergic receptor, glucose transporter, HMG-CoA reductase, cytochrome P-450 and tyrosine hydroxylase.
References in periodicals archive ?
To support kinase biology, Promega has just launched more than 100 individual full-length kinase target engagement assays.
PIM kinases named for the genomic site, Proviral Integration site of Moloney Murine leukemia virus.
The United States Food and Drug Administration's milestone approval in 2001 of the first kinase inhibitor, imatinib, was followed by a steady approval of kinase inhibitors over the next 10 years.
The research is targeted towards big and small pharma companies involved in the development of non-tyrosine kinase inhibitors for oncology.
In cases in which tyrosine kinase inhibitors are effective they reduce signaling via both the PI3K/AKT and MEK/ERK signaling pathways.
1]R also stimulate many intracellular nonreceptor tyrosine kinases, such as Src, Pyk2, p130Cas, FAK, and JAK/STAT (Eguchi and Inagami 2000).
Polo-like kinase-1 (PLK1) was identified as the principal protein kinase that carried out B23 phosphorylation at this site, and these findings point to PLK1 as a very promising cancer drug target.
P38 MAP kinase stimulates the proinflammatory factors tumor necrosis factor-[alpha], interleukin-1, and cyclooxygenase-2.
Receptor protein-tyrosine kinases and their signal transduction pathways.
HIV-1 gp120 and chemokine activation of pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
Kinases, which play a key role in cell signaling, have emerged as one of the most promising classes of drug discovery targets for pharmaceutical and biotechnology companies.