angiolymphoid hyperplasia with eosinophilia

(redirected from Kimura disease)

an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
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References in periodicals archive ?
The differential diagnosis includes Masson vegetant or papillary endothelial hyperplasia (a reactive endothelial proliferation associated with organizing thrombus/clot); Kimura disease (lymph node disorder, most often in Asian men, who have peripheral serum eosinophilia, reactive lymphoid follicles, follicular lysis, eosinophilic microabscesses, polykaryocytes, and IgE deposition); and angiosarcoma (freely anastomosing vessels, atypical endothelial cells, increased mitoses, necrosis).
Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions.
Kimura disease was first described in 1937 by Kim and Szeto in the Chinese literature as "eosinophilic hyperplastic lymphograuloma" (1) and was later characterized by Kimura et al in 1948 in a manuscript titled "On the unusual granulation combined with hyperplastic changes of lymphatic tissue.
Kimura disease is a rare benign chronic inflammatory disease that usually involves deep subcutaneous tissue and lymph nodes of the head and neck region with frequent regional lymphadenopathy or salivary gland enlargement.
Kimura disease is an uncommon chronic, benign, inflammatory condition of unknown etiology.
Kimura disease is a rare idiopathic condition that usually affects adolescent boys and young men of Asian descent.
3) In this article, the author reports a case of Kimura disease that manifested as bilateral postauricular masses and another case that manifested as a submandibular swelling.
Among the reactive conditions, Kimura disease was considered because of the clinical presentation of a tumorlike swelling in the submandibular subcutaneous area with typical lymphadenopathy.
Kimura disease is a rare, chronic inflammatory disorder that involves subcutaneous tissues, predominantly those in the head and neck region.
Kimura disease is sometimes confused with angiolymphoid hyperplasia with eosinophilia, Hodgkin lymphoma, angioimmunoblastic T-cell lymphoma, florid follicular hyperplasia, Castleman disease, and lymphadenopathy secondary to drug reactions and parasitic infections.
Kimura disease is a chronic disorder--usually a localized process without systemic symptoms--that follows an indolent clinical course.
According to Chen and Thompson in this month's Pathology Clinic, Kimura disease has a predilection for: