killer cells


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kill·er cells

cytotoxic cells involved in antibody-dependent cell-mediated immune responses; they possess receptors for the Fc portion of IgG molecules that lyse or damage IgG-coated target cells without mediation of complement. They are not MHC restricted. See: antibody-dependent cell-mediated cytotoxicity, CD8.
See also: natural killer cells.
Synonym(s): K cell (2) , null cells (1)

kill·er cells

(kil'ĕr selz)
Cytotoxic cells involved in antibody-dependent, cell-mediated immune responses.
Synonym(s): K cells, null cells (1) , T-cytotoxic cells.

killer cells

A subclass of large, granular LYMPHOCYTES that includes the natural killer (NK) cells and the killer (K) cells. These are important elements in the immune system and are the final effectors in the process by which damaged, infected or malignant cells are recognised and destroyed. At this stage in the process, killer cells act in conjunction with activated MACROPHAGES and cytotoxic T cells.
References in periodicals archive ?
Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for colon cancer.
Wang D, Ma Y, Wang J, Liu X, Fang M (2013) Natural killer cells in innate defense against infective pathogens.
Dr Quenby has estimated up to 3,000 unexplained miscarriages - a third of the annual total in the UK - could be prevented each year by giving a course of steroids to women who have suffered recurrent miscarriages and have elevated levels of natural killer cells.
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome.
a substance P antagonist (an experimental agent); they then measured natural killer cell activity in vitro.
Association of depression, CD8+ T lymphocytes, and natural killer cell activity: Implications for morbidity and mortality in human immunodeficiency virus disease.
The study, which found that long-term immune function decreases in proportion to how many times a woman has intentionally lost weight, measured natural killer cell activity in the women's blood.
Dr Siobhan Quenby, who carried out pioneering research at Liverpool Women's Hospital, said: "Everyone has killer cells to protect them from infection and cancer.
The investigators suspect that blocking SHIP may affect the response of natural killer cells.
This drug's biologic activities include activation of macrophages and natural killer cells, stimulation of interferon, and reactivation of cytokines.
The lymph system is composed of a network of vessels that mobilize fluids from every part of our body and groups of lymph nodes that house killer cells of the immune system.