Kikuchi disease


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Ki·ku·chi disease

(kē-kū'chē),
necrotizing lymphadenitis of unknown etiology characterized by lymph node enlargement, associated with fever that subsides spontaneously. Most often seen in young women in Japan but appears in other countries.

Kikuchi disease

A rare, idiopathic lesion of young women, which is characterised by painful localised, usually cervical, lymphadenopathy. 

Clinical findings
Fever or upper-respiratory tract symptoms, weight loss, nausea, vomiting, night sweats.

Lab
Increased interferon-gamma, IL-6 , FasL in acute phase, anti-nuclear antibodies, elevated ESR; 50% of cases have a mild reduction in neutrophils and increase in lymphocytes. 

Prognosis
Benign, self-limited; usually resolves in 1 to 4 months.
 
Note: Some authors regard Kikuchi’s disease as a forme fruste of systemic lupus erythematosus.

Ki·ku·chi dis·ease

(ki-kū'chē di-zēz')
Necrotizing lymphadenitis of unknown etiology, most often encountered in young women in Japan but also in other parts of the world; lymph node enlargement, associated with fever; subsides spontaneously.
References in periodicals archive ?
Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology.
Kikuchi disease is a rare and a self-limiting illness, usually characterized by cervical lymphadenopathy and fever, which has symptoms which may overlap with Hodgkin's lymphoma or Tuberculosis leading to misdiagnosis in some patients, ANA, APCA, Anti-ds DNA, RF is usually negative and may help in differentiating from SLE.
DISCUSSION: Kikuchi disease is a benign disorder of unknown cause with characteristic clinical findings and affected lymph nodes showing lesions with Karyorrhectic nuclear debris and proliferating mononuclear cells, including histiocytes, lymphoid cells and Plasmacytoid T cells/Plasmacytoid monocytes (CD68+), KFD was first described in 1972 by Kikuchi and Fujimoto.
A 26-year-old woman presented with recurrent Kikuchi disease 7 years after her initial episode.
Kikuchi disease is a self-limited illness characterized by lymphadenitis, fever, and leukopenia.
Some case reports show parotidomegaly and thyroiditis with kikuchi disease.
For the authors, remains the impression that the AKF appeared in a moment when KFD had stronger symptoms and when adequate treatment of Kikuchi disease reduced kidney failure.
Kikuchi disease is also known as Kikuchi-Fujimoto disease and histiocytic necrotizing lymphadenitis.
Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated.
staphylococcal and streptococcal infections, mycobacterial and fungal infections, tularemia, lymphogranuloma venereum, brucellosis, and leishmaniasis), Kikuchi disease, Kawasaki disease, and sarcoidosis.
In patient 1, the Kikuchi disease actually represented a recurrence of disease that had been undiagnosed a year earlier.