Keflex


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Related to Keflex: cephalexin

Keflex

 [kef´lex]
trademark for preparations of cephalexin, an oral cephalosporinantibiotic.

cephalexin

Apo-Cephalex, Biocef, Dom-Cephalexin, Keflex, Novo-Lexin, Nu-Cephalex, Panixine DisperDose, PMS-Cephalexin

Pharmacologic class: First-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis, causing cell to rupture and die. Active against many gram-positive bacteria; shows limited activity against gram-negative bacteria.

Availability

Capsules: 250 mg, 500 mg, 750 mg

Oral suspension: 125 mg/5 ml, 250 mg/5 ml

Tablets: 250 mg, 500 mg

Indications and dosages

Respiratory tract infections caused by streptococci; skin and skin-structure infections caused by methicillin-sensitive staphylococci and streptococci; bone infections caused by methicillin-sensitive staphylococci or Proteus mirabilis; genitourinary infections caused by Escherichia coli, P. mirabilis, and Klebsiella species; Haemophilus influenzae, methicillin-sensitive staphylococcal, streptococcal, and Moraxella catarrhalis infections
Adults: 1 to 4 g P.O. daily in divided doses (usually 250 mg P.O. q 6 hours). For uncomplicated cystitis, skin and soft-tissue infections, and streptococcal pharyngitis, 500 mg P.O. q 12 hours.
Children: 25 to 50 mg/kg/day P.O. in divided doses

Otitis media caused by S. pneumoniae
Children: 75 to 100 mg/kg/day P.O. in four divided doses

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to cephalosporins or penicillin

Precautions

Use cautiously in:
• renal impairment, phenylketonuria
• history of GI disease
• debilitated or emaciated patients
• elderly patients
• pregnant or breastfeeding patients.

Administration

• Give with or without food.
• Refrigerate oral suspension.

Adverse reactions

CNS: fever, headache, lethargy, paresthesia, syncope, seizures

CV: edema, hypotension, vasodilation, palpitations, chest pain

EENT: hearing loss

GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Musculoskeletal: joint pain

Respiratory: dyspnea

Skin: rash, maculopapular and erythematous urticaria

Other: superinfection, chills, pain, allergic reaction, hypersensitivity reactions including anaphylaxis, serum sickness

Interactions

Drug-drug.Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Chloramphenicol: antagonistic effect

Probenecid: increased cephalexin blood level

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, lactate dehydrogenase, lymphocytes: increased values
Coombs' test: false-positive result (especially in neonates whose mothers received drug before delivery)

Granulocytes, neutrophils, white blood cells: decreased counts

Patient monitoring

• Assess for signs and symptoms of serious adverse reactions, including hypersensitivity, severe diarrhea, and bleeding.
• During long-term therapy, monitor CBC and liver and kidney function test results.

Patient teaching

Instruct patient to stop taking drug and contact prescriber immediately if he develops rash or difficulty breathing.
• Tell patient to take drug with full glass of water.
• Advise patient to report severe diarrhea.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Keflex

(kĕf′lĕks′)
A trademark for the drug cephalexin.

Keflex

a trademark for an antibacterial (cephalexin).

Keflex

A brand name for CEPHALEXIN (cefalexin).
References in periodicals archive ?
Keflex is a cephalosporin class of antibiotics, with over 22m prescriptions dispensed annually.
The recommended treatment was to consider surgery, to administer oral Keflex plus TMP/SMX or clindamycin alone, or to administer intravenous clindamycin plus vancomycin or Zosyn (piperacillin sodium and tazobactam sodium) plus vancomycin.
Looking at market volumes in 1975, Lilly's market dollar volumes on Keflin, Keflex, and Kefzol were:
He was initially started on Keflex (Cephalexin) 250 mg three times daily for cellulitis.
My physician instructed me to take a Z-Pak if the cough wasn't getting better after the Keflex.
Many a physician has puzzled over this clinical scenario: You prescribe an oral [beta]-lactam, such as Keflex, for a patient with furunculosis.
MiddleBrook currently markets MOXATAG, the first and only FDA-approved once-daily amoxicillin, and KEFLEX (cephalexin, USP), the immediate-release brand of cephalexin.
If the culture subsequently indicates a susceptible form of infection, the child can be switched to Keflex (cephalexin).
The child is taken to the doctor where traditional oral antibiotics used to treat skin infections, such as Augmentin or Keflex, are begun.
s Keflex, and erythromycin ethylsuccinate for oral suspension as a generic equivalent of Abbot Laboratories' EES granules.
Amoxicillin * Amoxil, Biomox, Polymox, Trimox, Wymox Cephalexin * Biocef, Keflex Celecoxib * Celebrex Diclofenac/Misoprostol * Arthrotec Ipratropium * Atrovent Labetalol * Trandate Methyldopa * Aldomet Naproxen * Aleve, Anaprox, Naprosyn Nitrofurantoin * Furadantin, Macrobid, Macrodantin Rofecoxib * Vioxx Tiotropium * Spiriva Tolmetin * Tolectin Triamcinalone * Aristocort, Atolone, Kenacort Sulfamethoxazole/Trimethoprim * Bactrim, Cotrim, Septra, Sulfatrim Sulfisoxazole * Gantrisin
Nasdaq: MBRK) currently markets MOXATAG, the first and only FDA-approved once-daily amoxicillin, and KEFLEX (cephalexin, USP), the immediate-release brand of cephalexin.