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kallikrein-kinin system |
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kallikrein-kinin system
[kalik′rē·in-] a proposed hormonal system that functions within the kidney, with the enzyme kallikrein in the renal cortex mediating production of bradykinin, which acts as a vasodilator peptide. Kallikrein is present in blood plasma, urine, and tissues in an inactive state. Also spelled kallikren-kinin system. kallikrein (kal´ikrē´in), n a group of enzymes (plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen to bradykinin or kallidin; trypsin and plasmin can also affect the conversion. kallikrein-kinin system,
n a proposed hormonal system that functions within the kidney, with the en-zyme kallikrein in the re-nal cortex mediating production of bradykinin, which acts as a vasodilator peptide. kallikrein any of a group of proteolytic enzymes present in various glands, lymph, urine, blood plasma, etc., or produced directly from mast cells or basophils, or indirectly from activated platelets. The major action of kallikreins is the liberation of kinins from α-2-globulins (kininogens), and they hence have vasodilator and whealing actions. kallikrein-kinin system the enzyme system responsible for capillary permeability and smooth muscle contraction. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Topics of specific papers include regulation of cardiovascular control mechanisms, inflammation, aldosterone and vascular damage, calcitonin gene-related peptides and hypertension, the renal dopaminergic system, salt sensitivity, insulin resistance, fatty acids, cell signaling, goal-oriented hypertension management, the role of nitric oxide, the Kallikrein-Kinin system, sex steroids, and the lipoxygenase system in the vasculature. Hereditary angioedema is caused by an activation of the kallikrein-kinin system and increased bradykinin concentration. In patients with liver cirrhosis, the kallikrein-kinin system is considerably activated with Bradykinin being one of the most important inducers of microvascular leakage. |
kallikrein-kinin system |
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