KLK6

KLK6

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.

Molecular pathology
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.
References in periodicals archive ?
We observed that the mRNA expression levels of KLK6 were reduced by 99% and 64% in the UMSCC1 and OSC19 cells with increased miR-375 expression, respectively, compared to their control lines (Figure 8, A).
Several prognostic studies have shown that the combination of KLK6 with CA-125 enhances their diagnostic power (4,5).
Now, in a follow-up study, the group investigated the levels of KLK6 and other kallikreins in blood samples taken from 35 people with different clinical courses of MS and 62 controls without MS.
These genes include angiogenic/vascular cell growth factors (VEGF, PLGF, ADM, ANGPT2, TGFB2), vasoactive serine proteases (KLK2, KLK6, KLK9, KLK22), and vascular endothelial receptors (IL17R, BDKRB1, ENG, GNA13).
Recent work has demonstrated roles for KLK5 and 7 in skin desquamation (7), and for KLK6 in the brain (8).
30) found no overexpression of the 15 tissue kallikreins in breast cancer tissue compared with healthy breast tissue and down-regulation of the expression of at least 4 tissue kallikrein genes (KLK5, KLK6, KLK8, and KLK10) in breast cancer tissue.
For example, we found that KLK6 and KLK13 have a splice variant with 3'-coding exon 3 extension by ~100 by (close to the length of the retained intron III in the genes examined here).
The KLK6 gene encodes for a trypsin-like serine protease 244 amino acids in length, of which 16 amino acids constitute the signal peptide and 5 amino acids (Glu-Glu-Gln-Asn-Lys) constitute the activation peptide.
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
KLK6 (zyme/protease M) was isolated by differential display from an ovarian cancer library (57), and KLK10 (NES1) was cloned by subtractive hybridization from a breast cancer library (58) and later shown to act as a tumor suppressor gene (59).
On the basis of the amino acid sequences, the closest relatives of KLK4 within the human kallikrein gene family are those that encode PSA (38% identity), the human stratum corneum chymotryptic enzyme (45% identity), and KLK6 (zyme/ neurosin/protease M; 38% identity) (6); the last and KLK10 are implicated in ovarian cancer (7, 8).