KLK5

KLK5

A gene on chromosome 19q13.33 that encodes a protein thought to be involved in desquamation; it is expressed in the skin, breast, brain and  testes.
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The amounts of 18S rRNA and mRNAs encoded by KLK5, KLK6, KLK7, KLK10,
The KLK8 mRNAs were considered alone or as a ratio with the KLK5, KLK6, KLK7, KLK10, KLK11, KLK13, or KLK14 mRNA in the same samples.
Recent work has demonstrated roles for KLK5 and 7 in skin desquamation (7), and for KLK6 in the brain (8).
KLK5 was most abundant in skin (adult and fetal), with lower concentrations in the breast, esophagus, and salivary gland.
Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.
When we performed PCR on 36 healthy human tissue samples, we observed a second band, higher than the one expected for the classical form for the genes KLK1, KLK2, KLK5, and KLK15.
Fine mapping of the area indicates that KLK6 lies between the KLK5 and KLK7 genes (9).
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
KLK7 is up-regulated in ovarian cancer (62), and KLK4 and KLK5 are indicators of poor prognosis of ovarian cancer (63-65).
Human kallikrein gene 5 [designated KLK5 [5] according to the human gene nomenclature committee (21), and also known as kallikrein-like gene-2 (KLK-L2) (22) or human stratum corneum tryptic enzyme (HSCTE) (23)] is a newly identified member of the human kallikrein gene family that maps to chromosome 19813.
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.