KLF6

KLF6

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the Kruppel-like family of transcription factors; it activates transcription, acting as a tumour suppressor.

Molecular pathology
Some KLF6 transcription variants have been linked to carcinogenesis.
References in periodicals archive ?
By studying the functional role of the KLF6 tumor suppressor gene, Dr.
The incorrect splicing of the KLF6 gene essentially creates a protein that causes cancer cells to spread or metastasize.
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
Basically we're able to make FOXO1 turn on KLF6, which tells cancer cells to die," senior author Goutham Narla said in a telephone interview.
The anti-psychotic drug could also be potentially used to combat other kinds of tumors, since the FOXO1 and KLF6 defects found in lung cancer are also seen in some breast and prostate cancers.
Eight of these 12 highly associated SNPs were within or proximate to known genes {ADDS [adducin 3 (gamma)1, CD47 (CD47 molecule), RPS6KA2 (ribosomal protein S6 kinase, 90kDa, polypeptide 2), KLF6 (Kruppel-like factor 6), PARK2 [parkinson protein 2, E3 ubiquitin protein ligase (parkin)), MSRA (methionine sulfoxide reductase A), NRSNI (neurensin 1), and NRXNI (neurexin 1)} that likely interact through three networks (Figure 1) predicted by multiple binary protein--protein interactions as statistically associated in the curated published literature (Brennan a al.
Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.
He and his team are also responsible for the discovery of a novel tumor suppressor gene, KLF6 that is inactivated in a number of human cancers, including primary liver cancer.