KLF4

KLF4

A gene on chromosome 9q31 that encodes a protein of the Krüppel-like family of transcription factors that can act as an activator and repressor. KLF4 binds to its own promoter region and activates self-transcription; it regulates expression of key transcription factors during embryonic development and plays an important role in keeping embryonic stem cells in stasis, preventing their differentiation. KLF4 is required for the barrier function of the skin and the ocular surface. It is involved in epithelial cell differentiation and may play a role in skeletal and kidney development. KLF4 contributes to downregulating p53/TP53 transcription.
References in classic literature ?
Griffiths knew that Philip had looked after the girl while she was having her baby and was now going away with her.
I couldn't stand it if you boys were inconsiderate, or thought of her as if she were just somebody who looked after you.
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
Also, study revealed that KLF4 triggers MCP-1-induced protein (MCPIP) to stimulate ROS production in IL-4-induced M2 macrophages and ROS attenuation blocked ER stress in M2 macrophages.
Also, transcripts for OCT4, KLF4 and NANOG were identified in extracellular vesicles isolated from the cell culture media of PA embryos; additionally, levels of these transcripts were increased in NT embryos following the co-culture with PA embryos.
6 Furthermore Nelson and colleagues have shown that treatment with human stem cell factor OCT3/4 SOX2 KLF4 and c-MYC is able to induce embryonic stem cells into iPSCs form regenerative myocardial smooth muscle or endothelial vascular cells in situ repair myocardial infarction and increase ventricular wall thickness and electrical stability.
When A2bAR is expressed, KLF4 level is augmented, leading to inhibition of differentiation of fat stem cells.
11) KLF4 has an inhibitory effect on cellular growth in most cells, (12) and it is an important component of the p53 tumor suppressor pathway.
The second group included regulators of pluripotency pathways that were predicted to be activated, such as SOX2 (SRY-box containing gene 2), NANOG, KLF4 (Kruppellike factor 4), and OCT4.
Notably, the CDX2 protein is reported to silence the KLF4 gene as a critical oncogenic event in
The team, including Noriyuki Tsumaki, a professor at the university, introduced two genes -- c-MYC and KLF4, needed for creating iPS cells, and another gene, SOX9, necessary for the development of cartilage cells -- into the skin cells of a newborn using a virus.
Lebson is studying the role of an immune signaling molecule known as KLF4 in mice with the MS-like disease EAE.