KLF14

KLF14

A gene on chromosome 7q32.3 that encodes a member of the Kruppel-like zinc finger DNA-binding protein family induced by TGF-beta. KLF14 in turn represses TGF-beta receptor II expression.
References in periodicals archive ?
KLF14, Kroppel like factor 14, Regulates the transcription of also known as Basic various genes, including TGF transcription element binding [beta]R11.
One, called KLF14 - which is inherited from the mother - acted as a "master gene".
Others controlled by KLF14 play a role in body-mass index, cholesterol, insulin and glucose levels.
It was already known that the KLF14 gene is linked to type 2 diabetes and cholesterol levels but, until now, how it did this and the role it played in controlling other genes located further away on the genome was unknown.
They found an association between the KLF14 gene and the expression levels of multiple distant genes found in fat tissue, which means it acts as a master switch to control these genes.
These other genes found to be controlled by KLF14 are in fact linked to a range of metabolic traits, including body-mass index (obesity), cholesterol, insulin and glucose levels, highlighting the interconnectedness of metabolic traits.
Scientists have already known that the KLF14 gene is linked to type 2 diabetes and cholesterol levels but, until now, they did not know the role that it played in controlling other genes.
amp;nbsp;They found a link between the KLF14 gene and the expression levels of multiple distant genes found in fat tissue, which means it acts as a master switch to control these genes.
The DIAGRAM plus consortium observed that the T2D risk alleles at PPARG, FTO, IRS1, and the newly discovered gene KLF14, were associated with higher fasting insulin, with primary effect on insulin action, whereas 3 loci (TCF7L2, ARAP1, and CDKAL1) were found to be associated with reduced fasting insulin suggestive of [beta]-cell dysfunction (41).
Recently the DIAGRAM-plus consortium found an association of novel T2D loci KLF14 (rs972283 G allele) and insulin resistance (HOMA-IR) in addition to 2 previously known T2D/obesity loci, FTO and PPARG (41).
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.